In Edo period Japan (1603 to 1868), a strange new disease called the Redface Pox has begun to prey on the country's men. Within eighty years of the first outbreak, the male population has fallen to a quarter of the total female population. Women have taken on all the roles traditionally granted to men, even that of the Shogun. The men, precious providers of life, are carefully protected and the most beautiful of the men are sent to serve in the Shogun's Inner Chambers.
 
(Source: VIZ Media) 

Note: The first episode has a runtime of 1 hour and 18 minutes.

In Edo period Japan, a strange new disease called the Redface Pox has begun to prey on the country's men. Within eighty years of the first outbreak, the male population has fallen by seventy-five percent. Women have taken on all the roles traditionally granted to men, even that of the shogun. The men, precious providers of life, are carefully protected. And the most beautiful of the men are sent to serve in the shogun's Inner Chamber...
 
(Source: VIZ Media)
 
Notes: 
- Won an Excellence Prize at the 2006 Japan Media Arts Festival 
- Won a special prize at The Japanese Association of Feminist Science Fiction and Fantasy's fifth annual Sense of Gender Awards in 2005. 
- Won the Tezuka Osamu Cultural the Grand Prize in 2009 and the 56th Shogakukan Manga Award in Girls' Category in 2011. 
- Nominated for the first annual Manga Taishou in 2008.

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