Anubis, an ancient Egyptian evil that was defeated by Yugi's alter ego centuries ago, has returned to exact revenge. Wielding the power of the Eighth Millennium Item, Anubis is determined to destroy Yugi and take over the world.
 
(Source: Anime News Network)

Yu-Gi-Oh! Duel Monsters centers around the journey of the spirit of an ancient Egyptian pharaoh who is trying to re-discover who he was many years ago, since he has lost his memories. With the help of a boy, Yugi Mutou, the one who awakened the spirit, and his friends, he battles many villains and adversaries. Many of the villains have been linked to the Nameless Pharaoh's past, due to the Millennium Puzzle he holds and many try to take the puzzle and his power away from him. 
The series focuses on the card game aspect of it and the main theme represented throughout the series is friendship.

A card that surpasses the Three Mythic Gods!? Kaiba has obtained a mysterious card, the "Pyramid of Light"! Meanwhile, Yugi hears an ominous premonition involving Kaiba and the other Yugi that grasps Kaiba's own life and the fate of the two Yugis. A dangerous duel has begun! 
(Source: Tatsu no Kiba Productions)

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