Takuma Hirose is a blind young male high school student, though the cause for his blindness is undetermined. In order to heal his medical condition, he is sent to live in a village with his uncle. There, he meets several girls, three of which stand out more than any of the others. They are Hayami Kohinata, Hinata Kangura, and Otoha. Otoha temporarily heals his blindness and Hirose uses his sight to help others. He finds out that, for some reason, Hayami Kohinata is hated in the village, and he tries his best to help her out. Meanwhile, many sad secrets unfold in the village...

H2O's story revolves around Takuma Hirose, a blind young male junior-high school student, though the cause for his blindness is undetermined. After his mother died an unexpected death, it left a deep emotional scar on him, which caused him to become very lonely and reserved. Due to this, Takuma and his father move from the city out into a rural area and Takuma is enrolled into a new junior-high school. At his new school, he meets several new girls, though three of whom he gets to know the most out of anyone else. They are, the firm and obstinate Hayami Kohinata, the kind and obliging Hinata Kagura, and the cheerful and mysterious Otoha.

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