Sho and his friend, Tetsuro, stumble upon a strange orb-like mechanism, the Guyver Unit, in the woods. It physically bonds with Sho and turns him into the alien soldier, Guyver. His mission is to protect the Guyver Unit from the Japanese corporation known as Chronos. They are after it and two other units just like it. To retrieve the object, they send out vicious monsters known as Zoanoids. So no one is safe in Sho's life; not even himself.

Shou and his friend, Tetsurou, stumble upon a strange orb-like mechanism, the Guyver Unit, in the woods. It physically bonds with Shou and turns him into the alien soldier, Guyver. His mission is to protect the Guyver Unit from the Japanese corporation known as Chronos. They are after it and two other units just like it. To retrieve the object, they send out vicious monsters known as Zoanoids. So no one is safe in Shou's life; not even himself.

Sho and his friend Tetsurou stumble upon an odd alien artifact while walking through the woods. Then, the alien artifact breaks free of its metallic bonds and enters Sho's body, turning him into the Guyver. With this new power, Sho must do battle with the evil Chronos corporation and their genetically enhanced Zoanoids, who seek to get the Guyver back into their labs. No one close to Sho is safe from Chronos. He must fight.
 
(Source: Anime News Network)

Lurking under the facade of everyday life lies a dark world of pain and destruction.​ The world is controlled by a sinister brotherhood that hides their fangs behind masks of humanity.​ They are the Chronos Corporation.​ 
 
While investigating a mysterious explosion near his school,​ Sho Fukamachi happens upon the Chronos Corporation's greatest weapon: a techno organic suit of bio armor known as "the Guyver.​" But Chronos is determined to conceal their secrets at any cost.​ Sho soon finds himself relentlessly pursued by its army of horrific bio-monsters.​ With nowhere to run,​ Sho is forced to call upon the fearsome power of the Guyver and rip his opponents limb from limb in a desperate struggle for survival.​ 
 
(Source: Funimation)

The plot of this OVA is a rough adaptation of the first four chapters of the Guyver manga. It covers the same basic elements of these chapters; Genesis of the guyver, Fight with Vamore, Fight with Guyver 2 and the introduction of Guyver 3. Main differences are the exclusion of Tetsuro and his replacement by Mizuki, The replacement of Lisker with a female Agent "Valcuria", and thus a female Guyver 2. There is also a look at Sho's psychology of how he deals with his situation including a very harsh moment where his friends are assassinated in cold blood. 
One night, high school student Sho Fukamachi discovers a mysterious metal object. Then in a blinding flash of light, Sho finds that he has accidentally fused with the Guyver, a mecha of mysterious alien design. 
Now, to save his girlfriend, Mizuki Segawa, along with the entire world, Sho must become the Guyver to fight the Chronos Corporation and their biocreatures, called Zoanoids, who are hell-bent on world domination.

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